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KMID : 1103920130190040417
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Korean Journal of Hepatology
2013 Volume.19 No. 4 p.417 ~ p.420
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Severe ischemic bowel necrosis caused by terlipressin during treatment of hepatorenal syndrome
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Kim Hae-Rim
Lee Young-Sun
Yim Hyung-Joon
Lee Hyun-Joo
Ryu Ja-Young
Lee Hyun-Jung
Yoon Eileen L.
Lee Sun-Jae
Hyun Jong-Jin
Jung Sung-Woo
Koo Ja-Seol
Choung Rok-Sun
Lee Sang-Woo
Choi Jai-Hyun
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Abstract
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Terlipressin is a vasopressin analogue that is widely used in the treatment of hepatorenal syndrome or variceal bleeding. Because it acts mainly on splanchnic vessels, terlipressin has a lower incidence of severe ischemic complications than does vasopressin. However, it can still lead to serious complications such as myocardial infarction, skin necrosis, or bowel ischemia. Herein we report a case of severe ischemic bowel necrosis in a 46-year-old cirrhotic patient treated with terlipressin. Although the patient received bowel resection, death occurred due to ongoing hypotension and metabolic acidosis. Attention should be paid to patients complaining of abdominal pain during treatment with terlipressin.
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KEYWORD
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Terlipressin, Necrosis, Hepatorenal syndrome
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